Island Sweet Skunk is a sativa that provides an energetic, uplifted, creative buzz. The aroma and flavor are described as tropical and fruity. Best used to treat stress, fatigue, depression, pain, and nausea. Some strains of ISS can have high levels of CBD to help treat anxiety, inflammation, and muscle spasms. Originally a Canadian strain, Island Sweet Skunk is a descendant of Skunk #1.